EGFR CORE FUCOSYLATION, INDUCED BY HEPATITIS C VIRUS, PROMOTES TRIM40-MEDIATED-RIG-I UBIQUITINATION AND SUPPRESSES INTERFERON-I ANTIVIRAL DEFENSES

EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses

Abstract Aberrant N-glycosylation has been implicated in viral diseases.Alpha-(1,6)-fucosyltransferase (FUT8) is the sole T-Shirt enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis.Here we find that multiple viral envelope proteins, including Hepatitis C Virus (HCV)-E2, Vesicular stomatitis virus (VSV)-G, Severe

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Zoonotic onchocerciasis in Hiroshima, Japan, and molecular analysis of a paraffin section of the agent for a reliable identification

Japan is a country of high specific diversity of Onchocerca with eight species, the adults of two not yet known.Onchocerca dewittei japonica, a common filarial parasite of wild boar, Two Drawer Nightstand had been proved to be the agent of five zoonotic onchocerciasis in Kyushu island with morphological and molecular studies.The sixth case, at Hiro

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